Bijlage A Standards Forensic Toxicology (004.1): summary of conceptsin forensic toxicology

Standards Forensic Toxicology (004.1)

This document contains keywords of concepts of which an expert in the field of Forensic Toxicology should minimally have a basic knowledge. – Anatomy, physiology, biochemistry De datum van inwerkingtreding ligt voor de datum van uitgifte.

• – Pathophysiology and biochemical pathology
• – Clinical chemistry
• – Basics of pathological anatomy
• – Pharmaco/toxicodynamics
• – Pharmaco/toxicokinetics, including the effect of dosage forms (biopharmacy)
• – Pharmaco/toxicogenetics
• – Chemical structures: structure-activity relationships, working mechanisms, metabolism of xenobiotics
• – General toxicology: acute versus chronic toxicity; carcinogenicity, mutagenicity, teratogenicity
• – Clinical toxicology: symptoms and therapy in the event of overdose organ toxicity, side effects, interactions, addiction and habituation, effects of drugs on behaviour, clinical chemistry (influence of poisoning on clinical-chemical parameters)
• – Pathophysiology and biochemical pathology
• – Epidemiology of acute poisoning
• – Risk assessment of possible poisonous substances
• – Sampling, choice of material to be examined and analysed (in this context the interpretation of autopsy and necropsy/legal post-mortem results are important)
• – Post-mortem processes in bodily material (causes and effects)
• – Method development and method specifications (quality, quantity): pre-treatment, separation and detection
• – Method validation: quality requirements
• – Quality control
• – Stability: storing, preserving
• – Certification and accreditation
• – External Quality Assurance